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One or more keywords matched the following properties of Mutlu, Gokhan M.
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overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
One or more keywords matched the following items that are connected to Mutlu, Gokhan M.
Item TypeName
Concept Antithrombin III
Concept Diabetes Mellitus, Type 2
Concept Specific Pathogen-Free Organisms
Concept Interferon Type I
Concept Electron Transport Complex III
Concept Collagen Type I
Concept Glucose Transporter Type 3
Academic Article Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Academic Article Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling.
Academic Article Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury.
Academic Article Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Academic Article Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling.
Academic Article ß2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.
Academic Article Balancing the risks and benefits of oxygen therapy in critically III adults.
Academic Article Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Academic Article Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.
Academic Article Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Grant Role of alveolar macrophages in particulate matter-induced cardiopulmonary disease
Grant ChicAgo Center for Health and EnvironmenT (CACHET)
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